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Synthesis, characterization, and antifungal activity of biaryl-based bis(1,2,3-triazoles) using click chemistry

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Abstract

Click chemistry was used to synthesize a series of biaryl-based bis(1,2,3-triazoles). Their antifungal activity was evaluated against three soil-borne plant pathogenic fungi, viz. Rhizoctonia bataticola, Sclerotium rolfsii, and Fusarium oxysporum, using the food poison technique at concentrations of 62.5–500 μg/cm3.

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Acknowledgments

We thank the Principal of St. Stephen’s College, Delhi for providing facilities. We thank the Defence Research Development Organisation (DRDO) and University Grants Commission (UGC), Govt. of India, New Delhi for the grant for research projects. We are grateful to Dr. Vairmani, Head, Chemical & Instrumental Analysis, IICT, Hyderabad for mass spectrometric studies. We thank Prof. Amit Basu for introducing click chemistry to one of us (SVE) during a visit to Prof. David Cane’s laboratory in the Department of Chemistry, Brown University, Providence, RI, USA under a St. Stephen’s College–Brown University exchange program. One of the authors (LS) thanks UGC, New Delhi for the award of junior research fellowship.

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Authors and Affiliations

  1. St. Stephen’s College, University of Delhi, Delhi, 110007, India

    Manoj Gaur & S. V. Eswaran

  2. Division of Agricultural Chemicals, IARI, Pusa Road, Delhi, 110012, India

    Mayurika Goel & P. Dureja

  3. National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500007, India

    L. Sridhar & S. Prabhakar

  4. University of Massachusetts Boston, Boston, MA, USA

    Tara Devi S. Ashok

  5. National Brain Research Centre, Manesar, 122050, India

    P. Raghunathan

Authors
  1. Manoj Gaur
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  2. Mayurika Goel
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  3. L. Sridhar
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  4. Tara Devi S. Ashok
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  5. S. Prabhakar
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  6. P. Dureja
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  7. P. Raghunathan
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  8. S. V. Eswaran
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Corresponding author

Correspondence to S. V. Eswaran.

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Gaur, M., Goel, M., Sridhar, L. et al. Synthesis, characterization, and antifungal activity of biaryl-based bis(1,2,3-triazoles) using click chemistry. Monatsh Chem 143, 283–288 (2012). https://doi.org/10.1007/s00706-011-0652-x

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  • DOI: https://doi.org/10.1007/s00706-011-0652-x

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