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Succinimide sulfonic acid (SuSA): an efficient and recyclable catalyst for the chemoselective N-Boc protection of amines

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Abstract

Succinimide sulfonic acid (SuSA) as a stable reagent is easily prepared by the reaction of succinimide with neat chlorosulfonic acid. This compound is able to catalyze the chemoselective conversion of amines to their corresponding N-Boc protected derivatives with (Boc)2O. All reactions were performed under mild conditions, giving the desired products in good to high yields.

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Acknowledgments

We are thankful to the University of Guilan Research Council for the partial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, College of Science, University of Guilan, 41335, Rasht, Iran

    Farhad Shirini & Nader Ghaffari Khaligh

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  1. Farhad Shirini
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  2. Nader Ghaffari Khaligh
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Correspondence to Farhad Shirini.

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Shirini, F., Khaligh, N.G. Succinimide sulfonic acid (SuSA): an efficient and recyclable catalyst for the chemoselective N-Boc protection of amines. Monatsh Chem 143, 631–635 (2012). https://doi.org/10.1007/s00706-011-0612-5

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  • DOI: https://doi.org/10.1007/s00706-011-0612-5

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