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Facile one-pot synthesis of polysubstituted quinolines under solvent-free conditions using sulfamic acid as a reusable catalyst

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Abstract

A facile one-pot synthesis of polysubstituted quinoline derivatives has been demonstrated by using sulfamic acid as a reusable catalyst under solvent-free conditions. The synthetic method provides the basis and advantages of a simple experimental procedure and easy recovery and reuse of catalyst, which makes it a highly practical and environmentally benign pathway for the synthesis of polysubstituted quinolines. Interestingly, this one-pot synthesis could produce the products regioselectively in the presence of dis-symmetrical arylamines.

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Acknowledgments

The authors thank “the Fundamental Research Funds for the Central Universities” (JUSRP10905), the “Start-up grant of Jiangnan University” (1045210372090460) for financial support.

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Authors and Affiliations

  1. School of Chemical and Materials Engineering, Jiangnan University, 1800 Lihu Road, 214122, Wuxi, Jiangsu, People’s Republic of China

    Min Zhang, Biao Xiong, Wei Yang, D. N. T. Kumar & Yu-Qiang Ding

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  1. Min Zhang
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  2. Biao Xiong
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  3. Wei Yang
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  4. D. N. T. Kumar
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  5. Yu-Qiang Ding
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Correspondence to Min Zhang.

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Zhang, M., Xiong, B., Yang, W. et al. Facile one-pot synthesis of polysubstituted quinolines under solvent-free conditions using sulfamic acid as a reusable catalyst. Monatsh Chem 143, 471–478 (2012). https://doi.org/10.1007/s00706-011-0590-7

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  • DOI: https://doi.org/10.1007/s00706-011-0590-7

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