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Crystal habit modifications of imatinib mesylate under various precipitation conditions

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Abstract

Crystals of the α-form of imatinib mesylate with various habits (e.g., polyhedral-like and plate-like) were prepared from various organic solvents (e.g., butyl lactate, 4-methyl-2-pentanone, 2-methyl-2-butanol, 2-isopropoxyethanol, propyl ether) by several precipitation methods. The methods provide imatinib mesylate in a non-needle-shaped crystalline α-form. The crystal modification was identified by hot-stage microscopy, scanning electron microscopy, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRPD). The analyses by DSC, IR, and XRPD indicate that imatinib mesylate crystals with various habits have the same crystal structure. The plate-like habit has been also observed in the system where the organic solvent acts as a precipitant.

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Acknowledgments

This investigation was supported by the Slovak Research and Development Agency, grant no. 121/2009, and the Slovak Grant Agency, projects nos. VEGA 1/0660/09 and 1/0460/10.

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Authors and Affiliations

  1. Research and Development Department, Bel/Novamann Ltd., 820 04, Bratislava, Slovakia

    Miroslav Veverka

  2. Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia

    Peter Šimon

  3. Faculty of Material Science and Technology, Slovak University of Technology, 917 24, Trnava, Slovakia

    Ján Lokaj

  4. Faculty of Natural Sciences, Comenius University, 842 15, Bratislava, Slovakia

    Eva Veverková

Authors
  1. Miroslav Veverka
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  2. Peter Šimon
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  3. Ján Lokaj
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  4. Eva Veverková
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Corresponding author

Correspondence to Peter Šimon.

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Veverka, M., Šimon, P., Lokaj, J. et al. Crystal habit modifications of imatinib mesylate under various precipitation conditions. Monatsh Chem 143, 65–71 (2012). https://doi.org/10.1007/s00706-011-0562-y

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  • DOI: https://doi.org/10.1007/s00706-011-0562-y

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