Abstract
A simple and efficient procedure for chemoselective mono-N-Boc protection of various structurally diverse amines, amino acids, and peptides with di-tert-butyl dicarbonate using Amberlyst-15 as catalyst in ethanol is described. The catalyst can be readily separated from the reaction products with simple filtration and recovered for direct reuse. No competitive side-reactions such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were observed.
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Financial support of this work by the Research Council of Mazandaran University is gratefully acknowledged.
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Jahani, F., Tajbakhsh, M., Khaksar, S. et al. An efficient and highly chemoselective N-Boc protection of amines, amino acids, and peptides under heterogeneous conditions. Monatsh Chem 142, 1035–1043 (2011). https://doi.org/10.1007/s00706-011-0534-2
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DOI: https://doi.org/10.1007/s00706-011-0534-2