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Simple and efficient preparation of 3-substituted 6-(4-chlorophenyl)-9-methyl-12H-[1]benzofuro[3,2-e][1,2,4]triazolo[4,3-b][1,2]diazepines via a silylation–amination reaction

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Abstract

A series of new 3-substituted 6-(4-chlorophenyl)-9-methyl-12H-[1]benzofuro[3,2-e][1,2,4]triazolo[4,3-b][1,2]diazepines was synthesized from the corresponding bicyclic 1-(4-chlorophenyl)-3,5-dihydro-8-methyl-4H-[1]benzofuro[2,3-d][1,2]diazepin-4-one. The synthesis strategy makes use of silylation–amination as the key step, allowing a wide range of derivatives to be prepared.

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Authors and Affiliations

  1. L.M. Litvinenko Institute of Physical Organic and Coal Chemistry, National Academy of Sciences of Ukraine, 70, R.Luxemburg Str, Donetsk, 83114, Ukraine

    Alexander Eresko, Valerij Tolkunov & Sergej Tolkunov

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  1. Alexander Eresko
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  2. Valerij Tolkunov
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  3. Sergej Tolkunov
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Correspondence to Alexander Eresko.

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Eresko, A., Tolkunov, V. & Tolkunov, S. Simple and efficient preparation of 3-substituted 6-(4-chlorophenyl)-9-methyl-12H-[1]benzofuro[3,2-e][1,2,4]triazolo[4,3-b][1,2]diazepines via a silylation–amination reaction. Monatsh Chem 142, 931–934 (2011). https://doi.org/10.1007/s00706-011-0500-z

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  • DOI: https://doi.org/10.1007/s00706-011-0500-z

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