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Aluminum enhances the toxic effects of amyloid β-peptide on cell membranes and a molecular model

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Abstract

The amyloid β-peptide (Aβ) and aluminum are found, among other components, in the senile plaques of patients with Alzheimer’s disease. Aggregated Aβ and aluminum are toxic to neurons but the mechanism of accumulation and toxicity remains poorly understood. It has been proposed that Aβ and aluminum toxicity results from Aβ– and aluminum–membrane interactions. It was therefore of interest to study the effect that Aβ and aluminum could have on cell membranes. Thus, the interactions of Aβ(1-40), Aβ(1-42), and Al(III) with the human erythrocyte membrane and a molecular model of the erythrocyte membrane were examined by electron microscopy and X-ray diffraction, respectively. The molecular model consisted of bilayers built up of dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine, phospholipid classes located in the outer and inner monolayers of most cell membranes, respectively. Aβ(1-40) and Aβ(1-42) in the presence of Al(III) altered the erythrocyte membrane morphology and the structure of dimyristoylphosphatidylcholine bilayers, effects that were different and stronger than those induced by Aβ and Al(III) separately.

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References

  1. Eckert GP, Wood WG, Müller WE (2001) J Neural Transm 108:1051

    Article  CAS  Google Scholar 

  2. Eckert GP, Wood WG, Müller WE (2005) Subcell Biochem 38:319

    Article  CAS  Google Scholar 

  3. Lau TL, Ambroggio EE, Tew DJ, Cappai R, Masters CL, Fidelio GD, Barnham KJ, Separovic F (2005) J Mol Biol 356:759

    Article  Google Scholar 

  4. Demeester N, Baier G, Enzinger C, Goethals M, Vandekerckhove J, Rosseneu M, Labeur C (2000) Mol Membr Biol 17:219

    Article  CAS  Google Scholar 

  5. Ambroggio EE, Kim DH, Separovic F, Barrow CJ, Barnham KJ, Bagatolli LA, Fidelio GD (2005) Biophys J 88:2706

    Article  CAS  Google Scholar 

  6. Mason RP, Jacob RF, Walter MF, Mason PE, Avdulov NA, Chochina SV, Igbavboa U, Wood WG (1999) J Biol Chem 274:18801

    Article  CAS  Google Scholar 

  7. Shin RW, Lee VM, Trojanowski JQ (1994) J Neurosci 14:7221

    CAS  Google Scholar 

  8. Waschuk SA, Elton EA, Darabie AA, Fraser PE, McLaurin JA (2001) J Biol Chem 276:33561

    Article  CAS  Google Scholar 

  9. McLaurin J, Chakrabartty A (1997) Eur J Biochem 245:355

    Article  CAS  Google Scholar 

  10. Müller WE, Kirsch C, Eckert GP (2001) Biochem Soc Trans 29:617

    Article  Google Scholar 

  11. Yokel RA (2000) Neurotoxicology 21:813

    CAS  Google Scholar 

  12. Jansson ET (2001) J Alzheimer Dis 3:541

    CAS  Google Scholar 

  13. Rondeau V (2002) Rev Environ Health 17:107

    CAS  Google Scholar 

  14. Zatta P, Kiss T, Suwalsky M, Berthon G (2002) Coord Chem Rev 228:271

    Article  CAS  Google Scholar 

  15. Zatta P, Lucchini R, van Rensburg S, Taylor A (2003) Brain Res Bull 62:15

    Article  CAS  Google Scholar 

  16. Exley C, Korchazhkina O (2001) The association of aluminium and β amyloid in Alzheimer’s disease. In: Exley C (ed) Aluminium and Alzheimer’s disease. Elsevier, Amsterdam

    Google Scholar 

  17. Gupta VB, Anitha S, Hedge ML, Zecca L, Garruto RM, Ravid R, Shankar SK, Stein R, Shanmugavelu P, Rao KSJ (2005) Cell Mol Life Sci 62:143

    Article  CAS  Google Scholar 

  18. Kuo Y-M, Kokjohn TA, Kalback W, Luehrs D, Galsko DR, Chevallier N, Koo EH, Emmerling MR, Roher AE (2000) Biochem Biophys Res Commun 268:750

    Article  CAS  Google Scholar 

  19. Jayakumar R, Kusiak JW, Chrest FJ, Demehin A, Murali J, Wersto RP, Nagababu E, Ravi L, Rifkind JM (2003) Biochim Biophys Acta 1622:20

    CAS  Google Scholar 

  20. Mattson MP, Begley JG, Mark RJ, Furukawa K (1997) Brain Res 771:147

    Article  CAS  Google Scholar 

  21. Mark RJ, Hensley K, Butterfield DA, Mattson MP (1995) J Neurosci 15:6239

    CAS  Google Scholar 

  22. Goodall HB, Reid AH, Findlay DJ, Hind C, Kay J, Coghill G (1994) Dis Markers 12:271

    Google Scholar 

  23. Devaux PF, Zachowsky A (1994) Chem Phys Lipids 73:107

    Article  CAS  Google Scholar 

  24. Boon JM, Smith BD (2002) Med Res Rev 22:251

    Article  CAS  Google Scholar 

  25. Suwalsky M, Villena F, Norris B, Cuevas F, Sotomayor CP, Zatta P (2003) J Inorg Biochem 97:308

    Article  CAS  Google Scholar 

  26. Suwalsky M, Villena F, Norris B, Cuevas F, Sotomayor CP (2004) J Inorg Biochem 98:1061

    Article  CAS  Google Scholar 

  27. Suwalsky M, Zambenedetti P, Carpene E, IbnLkayat M, Wittkowski W, Zatta P (2004) J Inorg Biochem 98:2080

    Article  CAS  Google Scholar 

  28. Suwalsky M, Villena F, Norris N, Soto MA, Sotomayor CP, Messori L, Zatta P (2005) J Inorg Biochem 99:764

    Article  CAS  Google Scholar 

  29. Suwalsky M, Martínez F, Grzyb J, Strzalka K (2005) Chem Phys Lipids 134:69

    Article  CAS  Google Scholar 

  30. Suwalsky M, Castro R, Villena F, Sotomayor CP (2008) J Inorg Biochem 102:842

    Article  CAS  Google Scholar 

  31. Suwalsky M, Novoa V, Villena F, Sotomayor CP, Aguilar LF, Ronowska A, Szutowicz A (2009) J Inorg Biochem 103:797

    Article  CAS  Google Scholar 

  32. Suwalsky M (1996) Phospholipids bilayers. In: Salamone JC (ed) Polymeric materials encyclopedia, vol 7. CRC, Boca Raton

    Google Scholar 

  33. Sheetz MP, Singer SJ (1974) Proc Natl Acad Sci U S A 71:4457

    Article  CAS  Google Scholar 

  34. Mackinnon N, Ridgway J, Crowell KJ, Macdonald PM (2006) Chem Phys Lipids 139:85

    Article  CAS  Google Scholar 

  35. Vyas SB, Duffy LK (1995) J Protein Chem 14:633

    Article  CAS  Google Scholar 

  36. Pillot T, Goethals M, Vanloo M, Talussot C, Brasseur R, Vandekerckhove J, Rosseneu M, Lins L (1996) J Biol Chem 271:28757

    Article  CAS  Google Scholar 

  37. Mobley DL, Cox DL, Singh RRP, Maddox MW, Longo ML (2004) Biophys J 86:3585

    Article  CAS  Google Scholar 

  38. Curtain CC, Ali FE, Smith DG, Bush AI, Masters CL, Barnham KJ (2003) J Biol Chem 278:2977

    Article  CAS  Google Scholar 

  39. Drago D, Folin M, Baiguera S, Tognon G, Ricchelli F, Zatta P (2007) J Alzheimer Dis 11:33

    CAS  Google Scholar 

  40. Delacourte A, Ghestem A, Lemdani M, Ouddane B (2005) J Appl Neurosci 2005:1

    Google Scholar 

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Acknowledgments

The authors thank Fernando Neira for his valuable technical assistance. This work was supported by a grant from FONDECYT (1090041).

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Authors and Affiliations

  1. Faculty of Chemistry, University of Concepción, Concepción, Chile

    Mario Suwalsky

  2. Faculty of Agronomy, University of Concepción, Chillán, Chile

    Pedro Hernández

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  1. Mario Suwalsky
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  2. Pedro Hernández
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Correspondence to Mario Suwalsky.

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Suwalsky, M., Hernández, P. Aluminum enhances the toxic effects of amyloid β-peptide on cell membranes and a molecular model. Monatsh Chem 142, 431–437 (2011). https://doi.org/10.1007/s00706-011-0471-0

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  • DOI: https://doi.org/10.1007/s00706-011-0471-0

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