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Exploration on structure and anticonvulsant activity of transition metal complexes derived from an “end-off” compartmental bis-quinoxaline derivative with phthalazinyl-diazine as endogenous bridge

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Abstract

An oligoquinoxaline derivative with phthalazine core has been prepared by condensation of 1,4-dihydrazinophthalazine with 2,3-dichloroquinoxaline in dry ethanol followed by acid hydrolysis. Classical endogenous bridging of phthalazine core with its diazine fragment was established in the transition metal(II) complexes derived from the ligand system by using various physicochemical and spectral techniques. The organic host acts as a hexadentate chelate with N4O2 donating sites for coordination towards later first-row transition metal ions. Complexes are in good agreement with the octahedral geometry and found to be 1:1 electrolytes. All synthesized compounds were screened for anticonvulsant activity in Wistar rats by using maximal electroshock method. The ligand, and Co(II) and Ni(II) complexes show appreciable suppression towards electroshock-induced seizures.

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Acknowledgments

The authors thank the Department of Chemistry and USIC, Karnatak University, Dharwad for spectral and analytical facilities. Recording of FAB mass spectra (CDRI Lucknow) is gratefully acknowledged. S.B. thanks the University Grants Commission, New Delhi, India for awarding a Research Fellowship in Science for Meritorious Students.

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Authors and Affiliations

  1. Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad, 580 003, Karnataka, India

    Srinivasa Budagumpi, M. P. Sathisha, Sandeep P. Netalkar & Vidyanand K. Revankar

  2. Department of Chemical Engineering, Pusan National University, Pusan, 609-735, Republic of Korea

    Srinivasa Budagumpi

  3. Department of Chemistry, Technion - Israel Institute of Technology, 32000, Haifa, Israel

    Naveen V. Kulkarni

  4. Department of Pharmacology, Luqman College of Pharmacy, Gulbarga, 585 102, Karnataka, India

    D. K. Suresh

Authors
  1. Srinivasa Budagumpi
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  2. Naveen V. Kulkarni
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  3. M. P. Sathisha
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  4. Sandeep P. Netalkar
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  5. Vidyanand K. Revankar
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  6. D. K. Suresh
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Correspondence to Vidyanand K. Revankar.

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Budagumpi, S., Kulkarni, N.V., Sathisha, M.P. et al. Exploration on structure and anticonvulsant activity of transition metal complexes derived from an “end-off” compartmental bis-quinoxaline derivative with phthalazinyl-diazine as endogenous bridge. Monatsh Chem 142, 487–494 (2011). https://doi.org/10.1007/s00706-011-0462-1

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  • DOI: https://doi.org/10.1007/s00706-011-0462-1

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