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Synthetic utility of bifunctional thiophene derivatives and antimicrobial evaluation of the newly synthesized agents

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Abstract

The key intermediate ethyl 2-amino-5-benzoyl-4-methylthiophene-3-carboxylate was prepared by a Gewald reaction starting from benzoylacetone, sulfur, and ethyl cyanoacetate in the presence of diethylamine. This intermediate reacted with various reagents to afford different fused and polyfunctional substituted thiophenes. Antimicrobial screening of the synthesized compounds exhibited promising antimicrobial activities.

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Acknowledgments

The authors are extremely grateful to Dr. Tamer A. Mahmoud (Department of Chemistry of Natural and Microbial Products, National Research Center) for helping us to screen the newly synthesized compounds for antimicrobial activity.

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Author notes

  1. Ameen A. Abu-Hashem

    Present address: Chemistry Department, Faculty of Science, Jazan University, Jazan, 2097, Saudi Arabia

Authors and Affiliations

  1. Photochemistry Department, National Research Center, Dokki, Giza, 12622, Egypt

    Ameen A. Abu-Hashem & Khadiga M. Abu-Zied

  2. Green Chemistry Department, National Research Center, Dokki, Giza, 12622, Egypt

    Mohamed F. El-Shehry

Authors
  1. Ameen A. Abu-Hashem
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  2. Khadiga M. Abu-Zied
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  3. Mohamed F. El-Shehry
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Corresponding author

Correspondence to Mohamed F. El-Shehry.

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Abu-Hashem, A.A., Abu-Zied, K.M. & El-Shehry, M.F. Synthetic utility of bifunctional thiophene derivatives and antimicrobial evaluation of the newly synthesized agents. Monatsh Chem 142, 539–545 (2011). https://doi.org/10.1007/s00706-011-0456-z

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  • DOI: https://doi.org/10.1007/s00706-011-0456-z

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