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Efficient and improved syntheses of two key intermediates for functionalization of β-cyclodextrin at the secondary hydroxyl face

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Abstract

A new and improved method for the regioselective synthesis of mono-2-tosyl-β-cyclodextrin was achieved under aqueous conditions that do not require large amounts of polar organic solvents such as N,N-dimethylformamide (DMF), specific basic catalysts such as Cs2CO3, or flammable bases such as NaH. Moreover, mono-2,3-mannoepoxy-β-cyclodextrin was also synthesized in the same reaction system by prolonging the reaction time.

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Acknowledgments

Financial support from the Natural Science Foundation of Ningxia Medical University (No. XT201001) is gratefully acknowledged.

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Authors and Affiliations

  1. School of Pharmacy, Ningxia Medical University, 750004, Yinchuan, China

    Zhi-zhong Wang

  2. Ningxia Engineering Research Center for Hui Medicine Modernization, 750004, Yinchuan, China

    Zhi-zhong Wang, Xue-yan Fu, Gui-dong Dai & Hong-feng Quan

Authors
  1. Zhi-zhong Wang
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  2. Xue-yan Fu
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  3. Gui-dong Dai
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  4. Hong-feng Quan
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Correspondence to Zhi-zhong Wang.

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Wang, Zz., Fu, Xy., Dai, Gd. et al. Efficient and improved syntheses of two key intermediates for functionalization of β-cyclodextrin at the secondary hydroxyl face. Monatsh Chem 142, 317–319 (2011). https://doi.org/10.1007/s00706-011-0451-4

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  • DOI: https://doi.org/10.1007/s00706-011-0451-4

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