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Nanocrystalline magnesium oxide: a novel and efficient catalyst for facile synthesis of 2,4,5-trisubstituted imidazole derivatives

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Abstract

Nanocrystalline magnesium oxide with high specific surface area has been used as a novel and efficient catalyst for an improved and rapid synthesis of biologically active 2,4,5-trisubstituted imidazoles, by three-component, one-pot condensation of 1,2-diketones and aryl aldehydes, in excellent yields under solvent-free and conventional heating conditions. The method has several advantages, for example excellent yields, shorter reaction time, and use of a non-toxic and recyclable catalyst.

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Acknowledgments

We gratefully acknowledge the financial support from the Research Council of the University of Kashan.

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Authors and Affiliations

  1. Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, 87317-51167, Kashan, I.R. Iran

    Javad Safari, Shiva Dehghan Khalili & Sayed Hossein Banitaba

  2. Catalyst and Advanced Materials Research Laboratory, Chemical Engineering Department, Faculty of Engineering, University of Kashan, 87317-51167, Kashan, I.R. Iran

    Mehran Rezaei & Fereshteh Meshkani

Authors
  1. Javad Safari
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  2. Shiva Dehghan Khalili
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  3. Mehran Rezaei
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  4. Sayed Hossein Banitaba
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  5. Fereshteh Meshkani
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Correspondence to Javad Safari.

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Safari, J., Khalili, S.D., Rezaei, M. et al. Nanocrystalline magnesium oxide: a novel and efficient catalyst for facile synthesis of 2,4,5-trisubstituted imidazole derivatives. Monatsh Chem 141, 1339–1345 (2010). https://doi.org/10.1007/s00706-010-0397-y

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  • DOI: https://doi.org/10.1007/s00706-010-0397-y

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