Monatshefte für Chemie - Chemical Monthly

, Volume 141, Issue 8, pp 883–888 | Cite as

A facile and expeditious approach for the synthesis of 2-azetidinone derivatives via a multicomponent reaction

Original Paper


New organic reactions allow chemical transformations which were previously unknown. Therefore, new reactions are important contributions to progress in the field of organic synthesis. Herein, we are reporting a simple, one-pot, efficient three-component synthesis of novel 3-chloro-4-[4-(2-oxo-2H-chromen-4-ylmethoxy)phenyl]-1-phenylazetidin-2-one derivatives using 4-(2-oxo-2H-chromen-4-ylmethoxy)benzaldehydes, anilines, and chloroacetyl chloride in the presence of triethyl amine as a catalyst under different conditions. Taking into account environmental and economic considerations, the protocol presented here has the merits of simple operation, convenient work-up, being environmentally benign, and providing good yields. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, MS, and elemental analysis.

Graphical Abstract


Multicomponent reaction One-pot synthesis Coumarin 2-Azetidinones 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.P.G. Department of Studies in ChemistryKarnatak UniversityDharwadIndia

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