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Enhanced rate of intramolecular nitrile oxide cycloaddition and rapid synthesis of isoxazoles and isoxazolines

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Abstract

An enhanced rate of intramolecular nitrile oxide cycloaddition and hence a rapid synthesis of isoxazoles and isoxazolines is described. Formation of nitrile oxides from oximes using only 1 or 2 Eq (equivalents) of aqueous sodium hypochlorite solution is also described.

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Acknowledgments

We thank Prof. K. C. Majumdar for providing some chemicals. R. N. De is grateful to U.G.C. (New Delhi) and University of Kalyani for financial support.

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Authors and Affiliations

  1. Department of Chemistry, University of Kalyani, Kalyani, 741235, West Bengal, India

    Brindaban Roy & Rajendra Narayan De

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  1. Brindaban Roy
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  2. Rajendra Narayan De
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Correspondence to Brindaban Roy.

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Roy, B., De, R.N. Enhanced rate of intramolecular nitrile oxide cycloaddition and rapid synthesis of isoxazoles and isoxazolines. Monatsh Chem 141, 763–771 (2010). https://doi.org/10.1007/s00706-010-0323-3

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  • DOI: https://doi.org/10.1007/s00706-010-0323-3

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