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Highly efficient and selective methoxymethylation of alcohols and phenols catalyzed by reusable ZrO(OTf)2 under solvent-free conditions

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Abstract

Different primary, secondary, and tertiary alcohols were efficiently converted to their corresponding methoxymethyl ethers with formaldehyde dimethyl acetal in the presence of catalytic amounts of ZrO(OTf)2 at room temperature. Phenols were also methoxymethylated by this catalytic system. Advantages of using this catalytic system are the short reaction times, easy catalyst preparation, high product yield, solvent-free conditions, applicability for both alcohols and phenols, and reusability of the catalyst.

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Acknowledgments

We are thankful to the Center of Excellence of Chemistry of University of Isfahan (CECUI) for financial support of this work.

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Authors and Affiliations

  1. Catalysis Division, Department of Chemistry, University of Isfahan, 81746-73441, Isfahan, Iran

    Majid Moghadam, Shahram Tangestaninejad, Valiollah Mirkhani, Iraj Mohammadpoor-Baltork & Mostafa Khajehzadeh

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  1. Majid Moghadam
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  2. Shahram Tangestaninejad
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  3. Valiollah Mirkhani
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  4. Iraj Mohammadpoor-Baltork
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  5. Mostafa Khajehzadeh
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Correspondence to Majid Moghadam.

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Moghadam, M., Tangestaninejad, S., Mirkhani, V. et al. Highly efficient and selective methoxymethylation of alcohols and phenols catalyzed by reusable ZrO(OTf)2 under solvent-free conditions. Monatsh Chem 141, 641–647 (2010). https://doi.org/10.1007/s00706-010-0310-8

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  • DOI: https://doi.org/10.1007/s00706-010-0310-8

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