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Highly efficient three-component synthesis of 1H-indazolo[1,2-b]phthalazinetrione derivatives catalyzed by heteropolyacids

Monatshefte für Chemie - Chemical Monthly volume 141, pages 425–430 (2010)Cite this article

Abstract

Efficient one-pot condensation of aldehyde, dimedone, and phthalhydrazide has been achieved in the presence of a catalytic amount of tungstosilicic acid under solvent-free conditions. A variety of 1H-indazolo[1,2-b]phthalazinetrione derivatives were prepared in high to excellent yields in short time.

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Acknowledgments

We thank the National Natural Science Foundation of China (20872025), the Nature Science Foundation of Hebei Province (B2008000149), and the Research Foundation for the Graduate Program of Hebei Normal University for financial support.

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Authors and Affiliations

  1. The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050016, China

    Hong-Juan Wang, Xiao-Nan Zhang & Zhan-Hui Zhang

Authors
  1. Hong-Juan Wang
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  2. Xiao-Nan Zhang
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  3. Zhan-Hui Zhang
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Correspondence to Zhan-Hui Zhang.

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Wang, HJ., Zhang, XN. & Zhang, ZH. Highly efficient three-component synthesis of 1H-indazolo[1,2-b]phthalazinetrione derivatives catalyzed by heteropolyacids. Monatsh Chem 141, 425–430 (2010). https://doi.org/10.1007/s00706-010-0283-7

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  • DOI: https://doi.org/10.1007/s00706-010-0283-7

Keywords

  • Multicomponent reaction
  • 1H-indazolo[1,2-b]phthalazinetrione
  • Aldehyde
  • Phthalhydrazide
  • Heteropolyacid
  • Solvent-free conditions