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Synthesis of the DE synthon of racemic camptothecin

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Abstract

A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithiation, reduction, and hydrolysis in 29% overall yield.

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Acknowledgments

We gratefully acknowledge financial support from the Program for New Century Excellent Talents in University (NCET) and National Natural Science Foundation of China. We also thank the Laboratory of Organic Functional Molecules, Sino-French Institute of ECNU for support.

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Authors and Affiliations

  1. Department of Chemistry, Institute of Medicinal Chemistry, East China Normal University, 200062, Shanghai, People’s Republic of China

    Shanbao Yu, Yu Luo, Haiyan Liu, Haomin Liu & Wei Lu

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  1. Shanbao Yu
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  2. Yu Luo
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  3. Haiyan Liu
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  4. Haomin Liu
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  5. Wei Lu
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Correspondence to Wei Lu.

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Yu, S., Luo, Y., Liu, H. et al. Synthesis of the DE synthon of racemic camptothecin. Monatsh Chem 141, 245–249 (2010). https://doi.org/10.1007/s00706-009-0245-0

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  • DOI: https://doi.org/10.1007/s00706-009-0245-0

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