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Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides

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Abstract

The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)-6-azauracils and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt

    Nasser R. El-Brollosy

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  1. Nasser R. El-Brollosy
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Correspondence to Nasser R. El-Brollosy.

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Correspondence: Nasser R. El-Brollosy, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

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El-Brollosy, N. Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides. Monatsh Chem 139, 1483–1490 (2008). https://doi.org/10.1007/s00706-008-0948-7

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  • DOI: https://doi.org/10.1007/s00706-008-0948-7

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