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On synthesis and properties of hypericin-porphyrin hybrids

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Abstract

Two diastereomeric tetraphenylporphyrinyl-ω-hypericinyl-ethylenes were prepared and their properties investigated. The (Z)-diastereomer displayed an even higher photosensitization of singlet oxygen and/or reactive oxygen species than hypericin, whereas the (E)-configured derivative showed a somewhat weaker effect. Accordingly, hybridization of hypericin and porphyrin chromophores seems to be a promising target for the development of novel sensitizers for photodynamic therapy.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Linz, Austria

    Stefan Aigner & Heinz Falk

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  1. Stefan Aigner
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  2. Heinz Falk
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Correspondence to Heinz Falk.

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Correspondence: Heinz Falk, Department of Organic Chemistry, Johannes Kepler University Linz, 4040 Linz, Austria, Europe.

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Aigner, S., Falk, H. On synthesis and properties of hypericin-porphyrin hybrids. Monatsh Chem 139, 1513–1518 (2008). https://doi.org/10.1007/s00706-008-0940-2

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  • DOI: https://doi.org/10.1007/s00706-008-0940-2

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