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Ruthenium(III) chloride-catalyzed efficient protocol for ethyl diazoacetate insertion into the N–H bond of secondary amines

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Abstract

Ruthenium(III) chloride (1 mol%) alone can catalyze the insertion of ethyl diazoacetate into N–H bonds of various structurally and electronically diverse secondary cyclic amines under solvent-free conditions to afford the corresponding glycine esters in good yields under ambient conditions. Reactions with various aliphatic primary and aromatic amines examined, however, were unsuccessful.

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Authors and Affiliations

  1. Indian Institute of Chemical Technology, Hyderabad, India

    Ravi Varala, Ramu Enugala & Srinivas R. Adapa

Authors
  1. Ravi Varala
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  2. Ramu Enugala
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  3. Srinivas R. Adapa
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Corresponding author

Correspondence to Srinivas R. Adapa.

Additional information

Correspondence: Dr. Srinivas R. Adapa, Indian Institute of Chemical Technology, Hyderabad 500 007, India.

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Varala, R., Enugala, R. & Adapa, S. Ruthenium(III) chloride-catalyzed efficient protocol for ethyl diazoacetate insertion into the N–H bond of secondary amines. Monatsh Chem 139, 1369–1372 (2008). https://doi.org/10.1007/s00706-008-0927-z

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  • DOI: https://doi.org/10.1007/s00706-008-0927-z

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