Abstract
A series of twenty halomethylated β-enaminones [RC(O)CH=C(R 1)NR 3 R 4, where R = CF3,CCl3, CHCl2; R 1 = H, Me, Ph; R 3 = H, Me, Bu, Et; R 4 = Me, Et, Bu, allyl, tert-amyl, CH2CH2OH, Bn, Ph] were synthesized using the ionic liquid [bmim]BF4 at room temperature. It is demonstrated that this ionic liquid is a reaction medium suitable for the amination of β-alkoxyvinyl halomethyl ketones. The advantages of this method are the absence of solvents, short reaction times, and good yields.
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Correspondence: Marcos A. P. Martins, Núcleo de Química de Heterociclos – NUQUIMHE, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
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Martins, M., Guarda, E., Frizzo, C. et al. An ionic liquid as reaction medium for the synthesis of halo-containing β-enaminones at room temperature. Monatsh Chem 139, 1321–1327 (2008). https://doi.org/10.1007/s00706-008-0923-3
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DOI: https://doi.org/10.1007/s00706-008-0923-3