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Derivatives of benzothiadiazole-7-carboxylates: synthesis and biological activity

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Abstract

Salicylic acid (SA) and methyl jasmonate (MJ) are important plant signal molecules to cause systemic acquired resistance (SAR), while it’s reported that they also have wide spectrum antitumor activities. Benzothiadiazole-7-carboxylates are plant activators which can cause SAR just like SA and MJ. To investigate whether the benzothiadiazole-7-carboxylate family is endowed with anticancer activities, several benzothiadiazole-7-carboxylate derivatives are synthesized and their inhibition to P388 murine leukemia cell and A549 human lung cancer cell compared with MJ are evaluated. The data indicated that benzo-1,2,3-thiadiazole-7-carboxylic acid 2-benzoyloxyethyl ester has a higher inhibition ability to the cancer cell P388 and A549, compared with MJ.

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Authors and Affiliations

  1. Shanghai Key Lab of Chemical Biology, Shanghai, China

    Weiping Zhu, Zhenjiang Zhao & Yufang Xu

  2. School of Pharmacy, East China University of Science and Technology, Shanghai, China

    Weiping Zhu, Zhenjiang Zhao & Yufang Xu

Authors
  1. Weiping Zhu
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  2. Zhenjiang Zhao
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  3. Yufang Xu
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Correspondence to Yufang Xu.

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Correspondence: Yufang Xu, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

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Zhu, W., Zhao, Z. & Xu, Y. Derivatives of benzothiadiazole-7-carboxylates: synthesis and biological activity. Monatsh Chem 139, 1067–1071 (2008). https://doi.org/10.1007/s00706-008-0887-3

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  • DOI: https://doi.org/10.1007/s00706-008-0887-3

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