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A chemoselective and one-pot synthesis of 5-hydroxy and 7-hydroxy coumarin derivatives

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Abstract

An efficient one-pot reaction of dialkyl acetylenedicarboxylates with 2,4-dihydroxybenzo(or aceto)phenones in the presence of triphenylphosphine produces 5-hydroxy- and 7-hydroxycoumarin derivatives. The novel procedure features short reaction time, fairly good yields, and simple workup.

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Acknowledgment

We are grateful for the financial support of Mazandaran University of the Islamic Republic of Iran.

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Authors and Affiliations

  1. Department of Chemistry, University of Mazandaran, 47415, Babolsar, Iran

    Robabeh Baharfar, Seyed M. Vahdat & Fatemeh G. Hakimabadi

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  1. Robabeh Baharfar
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  2. Seyed M. Vahdat
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  3. Fatemeh G. Hakimabadi
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Correspondence to Robabeh Baharfar.

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Baharfar, R., Vahdat, S.M. & Hakimabadi, F.G. A chemoselective and one-pot synthesis of 5-hydroxy and 7-hydroxy coumarin derivatives. Monatsh Chem 140, 489–493 (2009). https://doi.org/10.1007/s00706-008-0078-2

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  • DOI: https://doi.org/10.1007/s00706-008-0078-2

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