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Synthesis of 5-spirocyclohexyl-2,4-dithiohydantoin derivatives: a potential anti-leishmaniasis agent

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An Erratum to this article was published on 12 February 2009

Abstract

A series of spiro-dithiohydantoins were synthesized by heating a mixture of 5-spirocyclohexyl-2,4-dithiohydantoin potassium salt and 3-chloropropanoyl chloride. These compounds were synthesized and evaluated for their activity against five Leishmanial strains in the promastigote stage in vitro. Seventy-two hours inoculation of a variety of products gave an IC 100 and average IC 50 values of 1.25 and 0.376 mg/cm3 against all Leishmanial strains tested.

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Acknowledgments

We thank the Institute of Biochemistry, University of Balochistan, Quetta, Pakistan, for facilities and Tropical Medicine London for providing us with various Leishmanial strains.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Ain Shams, Abbassia, 11566, Cairo, Egypt

    Abdel-Sattar S. Hamad Elgazwy & Saad R. Atta-Allha

  2. Department of Basic Science, Institute of Environmental Studies and Research, University of Ain Shams, Abbassia, 11566, Cairo, Egypt

    Sherif M. A. S. Keshk

Authors
  1. Abdel-Sattar S. Hamad Elgazwy
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  2. Saad R. Atta-Allha
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  3. Sherif M. A. S. Keshk
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Corresponding author

Correspondence to Abdel-Sattar S. Hamad Elgazwy.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00706-009-0112-z

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Hamad Elgazwy, AS.S., Atta-Allha, S.R. & Keshk, S.M.A.S. Synthesis of 5-spirocyclohexyl-2,4-dithiohydantoin derivatives: a potential anti-leishmaniasis agent. Monatsh Chem 140, 243–249 (2009). https://doi.org/10.1007/s00706-008-0063-9

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  • DOI: https://doi.org/10.1007/s00706-008-0063-9

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