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Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors

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Abstract

A short and efficient sequence for the synthesis of a series of 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines was developed. 1-Phenyl-2-(6-pyrimidinyl)-ethanones, obtained via Weinreb’s methodology, were used in a Hantzsch thiazole cyclization reaction, followed by introduction of the aniline moieties via nucleophilic substitution.

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Acknowledgments

We thank Syngenta Crop Protection, Basel, for generous financial support.

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Authors and Affiliations

  1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, 1060, Vienna, Austria

    Marko P. Sušnik, Michael Schnürch, Marko D. Mihovilovic & Peter Stanetty

  2. Institute for Chemical Technology and Analytics, Vienna University of Technology, Getreidemarkt 9/164, 1060, Vienna, Austria

    Kurt Mereiter

Authors
  1. Marko P. Sušnik
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  2. Michael Schnürch
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  3. Marko D. Mihovilovic
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  4. Kurt Mereiter
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  5. Peter Stanetty
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Correspondence to Peter Stanetty.

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Sušnik, M.P., Schnürch, M., Mihovilovic, M.D. et al. Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors. Monatsh Chem 140, 423–430 (2009). https://doi.org/10.1007/s00706-008-0047-9

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  • DOI: https://doi.org/10.1007/s00706-008-0047-9

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