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Synthesis of thiohydantoins under one-pot three-component solvent-free conditions

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Abstract

A direct and efficient one-pot three-component synthesis protocol was developed for the synthesis of thiohydantoins from readily and widely available substrates (isothiocyanates, ethyl chloroacetate, and amines) employing solvent-free conditions.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China

    Song Cao, Longjie Zhu, Chuanmeng Zhao, Xiuhong Tang, Huajun Sun, Xin Feng & Xuhong Qian

  2. Key Laboratory of Organofluorine Chemistry, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Shanghai, China

    Song Cao

Authors
  1. Song Cao
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  2. Longjie Zhu
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  3. Chuanmeng Zhao
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  4. Xiuhong Tang
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  5. Huajun Sun
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  6. Xin Feng
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  7. Xuhong Qian
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Corresponding author

Correspondence to Song Cao.

Additional information

Correspondence: Song Cao, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

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Cao, S., Zhu, L., Zhao, C. et al. Synthesis of thiohydantoins under one-pot three-component solvent-free conditions. Monatsh Chem 139, 923–926 (2008). https://doi.org/10.1007/s00706-007-0842-8

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  • DOI: https://doi.org/10.1007/s00706-007-0842-8

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