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Synthesis and antiinflammatory activity of some pyrimidines and thienopyrimidines using 1-(2-Benzo[d][1,3]dioxol-5-yl)vinyl)-4-mercapto-6-methylpyrimidine-5-yl)ethan-2-one as a starting material

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Abstract

In continuation to our search for new heterocyclic systems based antiinflammatories, the suggestion and synthesis of some pyrimidines, thienopyrimidines, and their derivatives, were herein realized. The pharmacological screening showed that many of these compounds have good antiinflammatory activity. The structure assignments of the new compounds are based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties are reported.

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Correspondence to Abd El-Galil E. Amr.

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Correspondence: Abd El-Galil Elsayed Amr, National Research Center, Organic Chemistry Department, Cairo, Dokki, Egypt.

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Ouf, N., Amr, AG. Synthesis and antiinflammatory activity of some pyrimidines and thienopyrimidines using 1-(2-Benzo[d][1,3]dioxol-5-yl)vinyl)-4-mercapto-6-methylpyrimidine-5-yl)ethan-2-one as a starting material. Monatsh Chem 139, 579–585 (2008). https://doi.org/10.1007/s00706-007-0793-0

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  • DOI: https://doi.org/10.1007/s00706-007-0793-0

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