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Amino Acid Derivatives, VI [1]: Synthesis, Antiviral, and Antimicrobial Evaluation of α-Amino Acid Esters Bearing a 1,2,3-Triazolo[4,5-d]pyrimidinedione Side Chain

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Summary.

A series of peptide and dipeptide derivatives conjugated with a 1,2,3-triazolo[4,5-d]pyrimidinedione residue were synthesized. The new compounds were evaluated in vitro for cytotoxicity against HAV-27 and HSV-1 and showed moderate activity. The prepared compounds were tested for antimicrobial activity against four different bacterial species, and they displayed different degrees of antibacterial activities or inhibitory actions.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt

    Adel A.-H. Abdel-Rahman

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  1. Adel A.-H. Abdel-Rahman
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Correspondence to Adel A.-H. Abdel-Rahman.

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Abdel-Rahman, AH. Amino Acid Derivatives, VI [1]: Synthesis, Antiviral, and Antimicrobial Evaluation of α-Amino Acid Esters Bearing a 1,2,3-Triazolo[4,5-d]pyrimidinedione Side Chain. Monatsh. Chem. 139, 61–68 (2008). https://doi.org/10.1007/s00706-007-0745-8

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  • DOI: https://doi.org/10.1007/s00706-007-0745-8

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