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Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives

Monatshefte für Chemie - Chemical Monthly volume 138, pages 715–724 (2007)Cite this article

Summary.

A series of substituted pyridine, pyrazoline, and thiopyrimidine derivatives were synthesized from 3-acetylpyridine, which was prepared from nicotinic acid as a naturally starting material. The pharmacological screening showed that many of these compounds have good analgesic and antiparkinsonian activities comparable to Voltarene® and Benzatropine® as reference drugs. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties for synthesized compounds are reported.

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Authors and Affiliations

  1. Natural Compounds Chemistry Department, National Research Centre, Dokki, Cairo, Egypt

    Nehad A. Abdel-Latif

  2. Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt

    Nermien M. Sabry & Ashraf M. Mohamed

  3. Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt

    Mohamed M. Abdulla

Authors
  1. Nehad A. Abdel-Latif
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  2. Nermien M. Sabry
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  3. Ashraf M. Mohamed
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  4. Mohamed M. Abdulla
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Correspondence to Nehad A. Abdel-Latif.

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Abdel-Latif, N., Sabry, N., Mohamed, A. et al. Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives. Monatsh. Chem. 138, 715–724 (2007). https://doi.org/10.1007/s00706-007-0656-8

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  • DOI: https://doi.org/10.1007/s00706-007-0656-8

  • Keywords. Nicotinic acid; Pyrazolines; Thiopyrimidine; Analgesic; Antiparkinsonian.