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Synthesis of 2,3-cis Stereomeric Emetamines via Reissert Compounds

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Summary.

Alkylation of Reissert compounds with certain benzoquinolizinone derivatives followed by hydrolytic cleavage afforded the core of the title compounds in a two step sequence. Finally, the lactam intermediates were reduced with DIBAH giving the target compounds, the structural and stereochemical assignments of which were achieved by 13C NMR spectroscopy.

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Authors and Affiliations

  1. Department Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, München, Germany

    Eberhard Reimann & Manfred Renz

Authors
  1. Eberhard Reimann
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  2. Manfred Renz
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Correspondence to Eberhard Reimann.

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Part of PhD thesis, LMU München, D

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Reimann, E., Renz, M. Synthesis of 2,3-cis Stereomeric Emetamines via Reissert Compounds. Monatsh. Chem. 138, 211–218 (2007). https://doi.org/10.1007/s00706-007-0601-x

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  • DOI: https://doi.org/10.1007/s00706-007-0601-x

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