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Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities

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Summary.

4-Aminobicyclo[2.2.2]octan-2-ones and -ols showed activity against the causative organisms of East African sleeping sickness and Malaria tropica. Several imino derivatives of the ketones were more active. Now hydrazono analogues and 3-hydroximino derivatives of the ketones and alcohols were synthesized. The structures of the obtained isomers were elucidated by NMR spectroscopy. A single phenylhydrazone exhibited quite good antitrypanosomal activity in the range of already known imino analogues.

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Graz, Austria

    Robert Weis & Werner Seebacher

  2. Swiss Tropical Institute, Basel, Switzerland

    Marcel Kaiser & Reto Brun

  3. Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, Graz, Austria

    Robert Saf

Authors
  1. Robert Weis
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  2. Marcel Kaiser
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  3. Reto Brun
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  4. Robert Saf
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  5. Werner Seebacher
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Correspondence to Robert Weis.

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Weis, R., Kaiser, M., Brun, R. et al. Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities. Monatsh. Chem. 137, 1365–1374 (2006). https://doi.org/10.1007/s00706-006-0535-8

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  • DOI: https://doi.org/10.1007/s00706-006-0535-8

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