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A Route to Amino Functionalized Hypericin Derivatives and their Chemical and Photochemical Properties Pertaining to Photodynamic Therapy

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Summary.

Syntheses of amino functionalized hypericin derivatives could be achieved starting from the recently prepared emodin derived 1,3,8-trimethoxy-6-amino-9,10-anthraquinone. Our strategies for the preparation of 10,11-didemethyl-10,11-diaminohypericin, 10,11-didemethyl-10,11-di(acetylamino) hypericin, and its hypericinoidic diazepine derivative include synthetical modifications on the levels of the anthraquinone, anthron, and the phenanthroperylenequinone system itself. The chemical as well as photochemical properties of these unique hypericin derivatives, which might constitute new photodynamic therapy agents, are reported.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Johannes Kepler University, 4040, Linz, Austria

    Bernd Lackner, Klaus Bretterbauer & Heinz Falk

  2. Institute for Chemical Technology of Organic Materials, Johannes Kepler University, 4040, Linz, Austria

    Clemens Schwarzinger

Authors
  1. Bernd Lackner
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  2. Klaus Bretterbauer
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  3. Clemens Schwarzinger
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  4. Heinz Falk
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Correspondence to Heinz Falk.

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Lackner, B., Bretterbauer, K., Schwarzinger, C. et al. A Route to Amino Functionalized Hypericin Derivatives and their Chemical and Photochemical Properties Pertaining to Photodynamic Therapy. Monatsh. Chem. 136, 2067–2082 (2005). https://doi.org/10.1007/s00706-005-0397-5

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  • DOI: https://doi.org/10.1007/s00706-005-0397-5

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