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Synthesis of Optically Active Isothiazole Derivatives from L-(α)-Amino Acids

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Summary.

Several enantiomerically pure 3,5-disubstituted isothiazol-5-ylideneamine hydrobromides were prepared by oxidation of chiral 3-amino-2,3-unsaturated thioamides. The starting thioamides derived from natural L-α-amino acids represent a novel group of synthetically useful chiral reactants.

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Authors and Affiliations

  1. Department of Organic Chemistry, Jagiellonian University, 30-060, Kraków, Poland

    Dariusz Cież

  2. NMR Laboratory, Faculty of Chemistry, Jagiellonian University, 30-060, Kraków, Poland

    E. Szneler

Authors
  1. Dariusz Cież
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  2. E. Szneler
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Correspondence to Dariusz Cież.

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Cież, D., Szneler, E. Synthesis of Optically Active Isothiazole Derivatives from L-(α)-Amino Acids. Monatsh. Chem. 136, 2059–2066 (2005). https://doi.org/10.1007/s00706-005-0353-4

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  • DOI: https://doi.org/10.1007/s00706-005-0353-4

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