Summary.
CD exciton chirality methods are described for the stereochemical assignment of organic compounds containing carboxylic acid groups. Using the chromophoric combination 2-naphthoate or 2-anthroate and 9-anthrylmethyl group the absolute stereochemistry of α- and β-hydroxy carboxylic acids can be deduced from a single CD measurement. Furthermore, as demonstrated with cyclic and acylic dicarboxylic acids, the direct esterification of sterically hindered carboxyl groups with 2-naphthol also allows the stereochemical assignment via CD spectroscopy.
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Fischbeck, A., Bartke, N. & Humpf, HU. New Applications of the CD Exciton Chirality Method. Stereochemical Assignment of Organic Compounds Containing Carboxylic Acid Groups. Monatshefte für Chemie 136, 397–410 (2005). https://doi.org/10.1007/s00706-004-0277-4
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DOI: https://doi.org/10.1007/s00706-004-0277-4