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Allosteric Modulators of the Tertiary Alkanebisamino-Type. Variation of the Substitution of the Middle Chain Nitrogens

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Summary.

Synthesis pathways of high flexibility for variously substituted alkanebisamine-type allosteric modulators of muscarinic receptors capable of passing the blood-brain barrier were developed starting either from N,N′-(hexane-1,6-diyl)bistosylamide or adipic acid chloride. Pharmacological evaluation of some representative compounds revealed the allosteric potency to fall in a submicromolar range.

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Authors and Affiliations

  1. Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074, Würzburg, Germany

    Rainer Pick & Ulrike Holzgrabe

  2. Institute of Pharmacy, Pharmacology and Toxicology, University of Bonn, 53121, Bonn, Germany

    Seraina Duda-Johner, Christian Tränkle & Klaus Mohr

Authors
  1. Rainer Pick
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  2. Seraina Duda-Johner
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  3. Christian Tränkle
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  4. Klaus Mohr
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  5. Ulrike Holzgrabe
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Corresponding author

Correspondence to Ulrike Holzgrabe.

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Pick, R., Duda-Johner, S., Tränkle, C. et al. Allosteric Modulators of the Tertiary Alkanebisamino-Type. Variation of the Substitution of the Middle Chain Nitrogens. Monatshefte für Chemie 135, 1539–1556 (2004). https://doi.org/10.1007/s00706-004-0218-2

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  • DOI: https://doi.org/10.1007/s00706-004-0218-2

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