Summary.
N-Alkylation of certain angularly substituted heterocycles by C2- and C3-units provided appropriate precursors to construct stereoselectively the erythrinanone and several erythrinanone type analogues by intramolecular Friedel-Crafts acylation. The resulting aromatic ketones were catalytically reduced affording the corresponding parent frameworks including the hitherto unknown tetracyclus A-norschelhammerane. On the other hand, the stereoselective reduction of the carbonyl moiety offered a convenient approach to 11-hydroxylated erythrinanes with the natural occurring β-configuration. The structures and the stereochemistry of the target compounds were proved by NMR spectroscopy.
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Part of PhD thesis, LMU München, D
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Reimann, E., Ettmayr, C. A Novel Stereoselective Synthesis of cis-Configured Erythrinane and Erythrinane Type Analogues. Monatshefte für Chemie 135, 959–972 (2004). https://doi.org/10.1007/s00706-003-0158-2
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DOI: https://doi.org/10.1007/s00706-003-0158-2