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β-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides

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Summary.

A synthesis of the amino sugar 2-amino-2,3-didesoxyribose is described. Starting from D-glucosamine, β-methylfuranoside was obtained in eight steps in 20% yield. This carbohydrate is a novel building block for nucleosides and for backbone modified antisense oligonucleotides with 2′–5′ amide linkages.

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Authors and Affiliations

  1. Institut für Pharmazeutische Chemie, Universität Wien, A-1090 Wien, Austria, , , , ,

    Johannes Winkler, Ernst Urban & Christian R. Noe

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  1. Johannes Winkler
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  2. Ernst Urban
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  3. Christian R. Noe
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Correspondence to Christian R. Noe.

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Winkler, J., Urban, E. & Noe, C. β-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides. Monatshefte für Chemie 135, 109–116 (2004). https://doi.org/10.1007/s00706-003-0086-1

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  • DOI: https://doi.org/10.1007/s00706-003-0086-1

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