Summary.
The reaction of 3-chloro-5,6-diphenylpyridazine-4-carbonitrile with potassium thiocyanate gave the corresponding isothiocyanate derivative. This was reacted with aromatic amines in ethanol to afford pyrimido[4,5-c]pyridazine derivatives. The reaction of the latter compounds with hydrazine hydrate led to the formation of 6-hydrazino derivatives. One hydrazino compound was reacted with a variety of reagents to produce other new pyrimidopyridazines as well as a number of s-triazolo derivatives.
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Abdel Moneam, M. Synthesis and Reactions of Novel Pyrimido[4,5-c]pyridazine and s-Triazolo[3′,4′:2,3]pyrimido[4,5-c]pyridazine Derivatives. Monatshefte für Chemie 135, 45–53 (2004). https://doi.org/10.1007/s00706-003-0078-1
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DOI: https://doi.org/10.1007/s00706-003-0078-1