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Regioselective Heteroannelation in 4-Cyanomethyl-3,5-pyridinedicarbonitriles. Synthesis of 6-Alkoxy-3-dialkylamino-1,8-diamino-2,7-naphthyridine-4-carbonitriles

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Summary.

 The title naphthyridines were found to be the sole products obtained after treatment of 2-amino-4-cyanomethyl-6-dialkylamino-3,5-pyridinedicarbonitriles with alkoxides. The starting pyridine derivatives were prepared by amination of the readily available 2-amino-6-chloro-4-cyanomethyl-3,5-pyridinedicarbonitrile in quantitative yields.

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Authors and Affiliations

  1. Kiev National Taras Shevchenko University, 01033 Kiev, Ukraine, , , , , , UA

    Anton V. Tverdokhlebov, Elizaveta V. Resnyanska & Andrey A. Tolmachev

  2. Chernigov State University of Technology, 14027 Chernigov, Ukraine, , , , , , UA

    Alexander V. Zavada

Authors
  1. Anton V. Tverdokhlebov
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  2. Elizaveta V. Resnyanska
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  3. Andrey A. Tolmachev
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  4. Alexander V. Zavada
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Corresponding author. E-mail: atver@mail.univ.kiev.ua

Received November 4, 2002; accepted November 22, 2002 Published online May 6, 2003

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Tverdokhlebov, A., Resnyanska, E., Tolmachev , A. et al. Regioselective Heteroannelation in 4-Cyanomethyl-3,5-pyridinedicarbonitriles. Synthesis of 6-Alkoxy-3-dialkylamino-1,8-diamino-2,7-naphthyridine-4-carbonitriles. Monatshefte für Chemie 134, 1045–1052 (2003). https://doi.org/10.1007/s00706-003-0006-4

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  • DOI: https://doi.org/10.1007/s00706-003-0006-4

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