A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 3. Application of the Model-1

Summary.

 Using a previously reported physical-mathematical (biokinetic) model which dealt with the factors influencing the development of mismatch-dependent cells and DNA-proofreading and -repair and which model has been calibrated according to related experimental data available in the literature or determined from own preliminary tests, the known efficacy of classical cancer-therapies like surgical-tumor-extraction, or chemotherapy can be demonstrated via biokinetics. On the other hand, also other effects, as they have been reported recently in the literature upon a significant increase of mutants in cases of an inhibition of the proofreading and repair system, can be well described by the model.

Following the predictions of the model also in an opposite way, i.e. as to the consequences which arise, if the enzymatic proofreading- and repair-machinery were stimulated instead of inhibited, an interesting chance for a new, “soft” cancer-therapy results. According to this, the administration of proofreading- and repair-stimulators like f.e. equimolar combinations of purine- and pyrimidine-nucleotides’ precursors should open the possibility for an adjuvant cancer-therapy, especially as a cancer-prophylaxis (i.e., against cancers “in statu nascendi”) but also as postsurgical safety-measure. The results of first preclinical tests are reported.