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Archives of Virology

, Volume 146, Issue 10, pp 2021–2027 | Cite as

Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes

  • T. Ikegami
  • A. B. Calaor
  • M. E. Miranda
  • M. Niikura
  • M. Saijo
  • I. Kurane
  • Y. Yoshikawa
  • S. Morikawa
Brief Report

Summary.

 We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.

Keywords

Nucleotide Genome Sequence Complete Genome Intergenic Region Genome Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 2001

Authors and Affiliations

  • T. Ikegami
    • 1
  • A. B. Calaor
    • 3
  • M. E. Miranda
    • 3
  • M. Niikura
    • 1
  • M. Saijo
    • 1
  • I. Kurane
    • 1
  • Y. Yoshikawa
    • 2
  • S. Morikawa
    • 1
  1. 1. Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Tokyo, JapanJP
  2. 2. Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, JapanJP
  3. 3. Veterinary Research Department, Research Institute for Tropical Medicine, Muntinlupa, The PhilippinesPH

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