Summary
The fusion glycoprotein (F protein) of paramyxoviruses plays a vital role in virus-induced cytopathology. To explore the role of the F protein in peste des petits ruminants virus (PPRV)-induced cytopathology, the F protein of PPRV was purified by immunoaffinity chromatography. The purified F protein, when incubated with chicken erythrocytes, caused lysis suggesting that PPRV F protein is a hemolysin. Furthermore, the hemolysis can be inhibited by hyperimmune serum against F protein. The virus-induced cell fusion (syncytia) was also inhibited by the hyperimmune serum against the F protein. In summary, these results indicate that the purified PPRV F protein is biologically active and is involved in virus-induced hemolysis, cell-fusion and the initiation of infection.
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Received October 21, 1998 Accepted December 31, 1998
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Devireddy, L., Raghavan, R., Ramachandran, S. et al. The fusion protein of peste des petits ruminants virus is a hemolysin. Arch. Virol. 144, 1241–1247 (1999). https://doi.org/10.1007/s007050050583
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DOI: https://doi.org/10.1007/s007050050583