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Role of angiotensin II in cellular entry and replication of dengue virus

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Abstract

Previous studies have demonstrated the relevance of several soluble molecules in the pathogenesis of dengue. In this regard, a possible role for angiotensin II (Ang II) in the pathophysiology of dengue has been suggested by the observation of a blockade of Ang II in patients with dengue, increased expression of molecules related to Ang II production in the plasma of dengue patients, increased expression of circulating cytokines and soluble molecules related to the action of Ang II, and an apparent relationship between DENV, Ang II effects, and miRNAs. In addition, in ex vivo experiments, the blockade of Ang II AT1 receptor and ACE-1 (angiotensin converting enzyme 1), both of which are involved in Ang II production and its function, inhibits infection of macrophages by DENV, suggesting a role of Ang II in viral entry or in intracellular viral replication of the virus. Here, we discuss the possible mechanisms of Ang II in the entry and replication of DENV. Ang II has the functions of increasing the expression of DENV entry receptors, creation of clathrin-coated vesicles, and increasing phagocytosis, all of which are involved in DENV entry. This hormone also modulates the expression of the Rab5 and Rab7 proteins, which are important in the endosomal processing of DENV during viral replication. This review summarizes the data related to the possible involvement of Ang II in the entry of DENV into cells and its replication.

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Acknowledgements

We thank Instituto de Investigaciones Cllnicas Dr. Américo Negrette, Facultad de Medicina, Universidad de Zulia, Maracaibo, Venezuela.

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Authors and Affiliations

  1. Cátedra de Inmunología, Escuela de Bioanálisis, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela

    Adriana Pedreañez

  2. Instituto de Investigaciones Clínicas “Dr. Américo Negrette”, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela

    Yenddy Carrero, Renata Vargas, Juan P. Hernández-Fonseca & Jesús Alberto Mosquera

  3. Servicio de Microscopia Electrónica del Centro Nacional de Biotecnología (CNB- CSIC), Madrid, España

    Juan P. Hernández-Fonseca

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Contributions

JM-S and AP conceived the subject matter and contributed to the design of the work. JM-S, AP, YC, JPH-F, and RV contributed to the acquisition, analysis, or interpretation of data. JM-S and AP wrote the original draft. JM-S, AP, YC, RV, and JPH-F critically revised the first draft. All authors approved the final version of the manuscript.

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Correspondence to Jesús Alberto Mosquera.

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Pedreañez, A., Carrero, Y., Vargas, R. et al. Role of angiotensin II in cellular entry and replication of dengue virus. Arch Virol 169, 121 (2024). https://doi.org/10.1007/s00705-024-06040-4

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