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Foot-and-mouth disease virus strains isolated in Vietnam during 2010-2019: genetic characterization and antigenic relatedness to the Euro SA vaccine

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Abstract

Foot-and-mouth disease is a highly contagious disease that affects cloven-hoofed animals. It has an important socio-economic impact on the livestock industry because it produces a drastic decrease of productivity. The disease has been successfully eradicated from some regions, including North America and Western Europe, but it is still endemic in developing countries. Agriculture plays an important role in the national economy of Vietnam, to which animal production contributes a great proportion. The concurrent circulation of foot-and-mouth disease virus (FMDV) serotypes O, A, and Asia 1 has been detected in recent years, but serotype O remains the most prevalent and is responsible for the highest numbers of outbreaks. Appropriate vaccine strain selection is an important element in the control of FMD and is necessary for the application of vaccination programs in FMD-affected regions. Here, we present updated information about the genetic and antigenic characteristics of circulating strains, collected from endemic outbreaks involving types O and A, between 2010 and 2019. Neutralizing assays showed a good in vitro match between type O strains and the monovalent O1 Campos vaccine strain. High r1 values were obtained (above 0.7) when testing a swine serum pool collected 21 days after vaccination, but the O/VTN/2/2019 strain was an exception. An EPP estimation resulted in a median neutralizing titre of about 1.65 log10, indicating that good protection could be achieved. For type A Asia SEA 97 lineage strains, acceptable individual neutralizing titres were obtained with estimated EPP values over 80% for different combinations of vaccine strains. Taking into account that the r1 value is one tool of a battery of tests that should be considered for estimating the cross-protection of a field strain against a vaccine strain, an in vivo challenge experiment was also performed, yielding a PD50 value of 8.0. The results indicate that South American strains could be potentially used for controlling outbreaks involving these lineages. This study demonstrates the importance of considering strain characteristics when choosing vaccine strains and controls.

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Acknowledgments

We thank Dr. Carolina Artuso for her assistance in the sequencing technique procedure. Some of the data were presented previously as a poster at the VIth Global Foot-and-Mouth Disease Research Alliance (GFRA) Meeting, 2021.

Funding

Laboratory work was funded with SENASA’s own resources. Sample collection and identification were funded by RAHO 6, DAH Vietnam.

Author information

Authors and Affiliations

  1. Laboratorio de Referencia OMSA Para Fiebre Aftosa, Dirección de Laboratorio Animal, SENASA, CP1640, Martínez Buenos Aires, Argentina

    Ana I. Taffarel, Melanie Y. Barrios Benito & Sabrina Galdo Novo

  2. Department of Animal Health, Regional Animal Health Office (RAHO) No 6, Ho Chi Min, QMW4, Vietnam

    Vo V. Hung & Nguyen T. Phuong

  3. Biogenesis Bago, Garin, CP1619, Buenos Aires, Argentina

    Sabrina Cardillo & Cecilia Caldevilla

Authors
  1. Ana I. Taffarel
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  2. Melanie Y. Barrios Benito
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  3. Vo V. Hung
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  4. Sabrina Cardillo
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  5. Nguyen T. Phuong
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  6. Cecilia Caldevilla
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  7. Sabrina Galdo Novo
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Corresponding author

Correspondence to Sabrina Galdo Novo.

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Taffarel, A.I., Barrios Benito, M.Y., Hung, V.V. et al. Foot-and-mouth disease virus strains isolated in Vietnam during 2010-2019: genetic characterization and antigenic relatedness to the Euro SA vaccine. Arch Virol 169, 44 (2024). https://doi.org/10.1007/s00705-024-05960-5

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