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A novel mitovirus isolated from the filamentous fungus Hypoxylon fendleri

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Abstract

Members of the fungal genus Hypoxylon of the family Xylariaceae are known to produce secondary metabolites with significant chemical diversity. There are more than 200 species in the genus, including the filamentous fungus Hypoxylon fendleri. To the best of our knowledge, there have been no reports of mycoviruses in H. fendleri. In this study, a novel mycovirus, designated “Hypoxylon fendleri mitovirus 1” (HfMV1), was isolated from this fungus. The genome of HfMV1 is 2850 nt in length with a G + C content of 36% and contains a large open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp). BLASTp analysis revealed that the RdRp domain of HfMV1 had 28.30–50.90% sequence identity to those of members of the genus Duamitovirus and had the highest identity (50.90%) to Fusarium graminearum mitovirus 2-2 (FgMV2-2). Phylogenetic analysis further indicated that HfMV1 is a member of the genus Duamitovirus of the family Mitoviridae. This is the first report of a mycovirus in H. fendleri.

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Data availability

The data supporting this study's findings are available in the GenBank database.

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Acknowledgements

This work was supported by the Guizhou Provincial Science and Technology Projects (Grant numbers ZK [2021]081, [2018]5779-53).

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Author notes

  1. Xiang Li and Fang Ding contributed equally to this study.

Authors and Affiliations

  1. Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Biology and Engineering/School of Basic Medical Sciences, Guizhou Medical University, Guiyang, 550025, China

    Xiang Li, Fang Ding, Lina Zeng, Lili Liu, Hongmei Liu & Tingting Zhang

  2. Immune Cells and Antibody Engineering Research Center of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550025, China

    Xiang Li, Fang Ding, Lina Zeng, Lili Liu, Hongmei Liu & Tingting Zhang

  3. Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550025, China

    Tingting Zhang

Authors
  1. Xiang Li
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  2. Fang Ding
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  3. Lina Zeng
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  4. Lili Liu
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  5. Hongmei Liu
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Correspondence to Lili Liu, Hongmei Liu or Tingting Zhang.

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This study did not include experiments with human participants or animals performed by any of the authors.

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Li, X., Ding, F., Zeng, L. et al. A novel mitovirus isolated from the filamentous fungus Hypoxylon fendleri. Arch Virol 168, 198 (2023). https://doi.org/10.1007/s00705-023-05811-9

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  • DOI: https://doi.org/10.1007/s00705-023-05811-9

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