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Synthetic dibenzylideneketones as promising anti-herpes simplex virus type 1 agents

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Abstract

New antiviral agents for the treatment of herpes simplex virus type 1 (HSV-1) infection, which causes a highly prevalent and incurable disease, are needed. Here, we report for the first time the in vitro anti-HSV-1 activity of two dibenzylideneketone compounds: DBK1 and DBK2. DBK1 demonstrated virucidal activity, and high-resolution scanning electron microscopy showed that it caused morphological changes in the HSV-1 envelope. DBK2 was able to reduce HSV-1 plaque size in vitro. The DBKs are promising anti-HSV-1 candidates, as they exhibit low toxicity and exert an antiviral effect by acting at the early stages of HSV-1-host cell interaction.

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Fig 1
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Data availability

The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

The authors are grateful to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Financiadora de Estudos e Projetos (FINEP) for financial support, and to Complexo de Centrais de Apoio à Pesquisa (COMCAP/UEM) for research facilities. The authors thank Dr. Érica Benassi Zanqueta for assistance in the development of this work.

Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Financiadora de Estudos e Projetos (FINEP).

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Author notes

  1. Thalita Zago Oliveira

    Present address: Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil

Authors and Affiliations

  1. Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil

    Dyenefer Pereira Fonseca, André Henrique dos Santos, Thays Rosa da Silva, Danielle Lazarin-Bidóia, Benedito Prado Dias Filho, Celso Vataru Nakamura & Tania Ueda-Nakamura

  2. Laboratory of Micromolecular Biochemistry of Microorganisms, Federal University of São Carlos, São Carlos, São Paulo, Brazil

    Zia Ud Din & Edson Rodrigues-Filho

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  1. Thalita Zago Oliveira
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Contributions

All authors participated in the research and/or preparation of the article: TU-N was responsible for conception and design of the study, TZO performed the experiments of cytotoxicity and antiviral activity and wrote the manuscript, DPF and TRdS performed the antiviral assays, AHdS and DL-B performed the experiments of scanning electron microscopy, ZUD and ER-F were responsible for the preparation and chemical characterization of the dibenzylideneketones compounds, BPDF and CVN contributed by advising on experiments and through critical reading and feedback of the manuscript. All authors have read and approved the final article.

Corresponding author

Correspondence to Tania Ueda-Nakamura.

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All of the authors declare that there is no conflict of interest.

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Oliveira, T.Z., Fonseca, D.P., dos Santos, A.H. et al. Synthetic dibenzylideneketones as promising anti-herpes simplex virus type 1 agents. Arch Virol 168, 153 (2023). https://doi.org/10.1007/s00705-023-05777-8

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  • DOI: https://doi.org/10.1007/s00705-023-05777-8

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