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Complete genomic analysis of rabbit rotavirus G3P[22] in China

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Abstract

A rabbit rotavirus Z3171 isolate from diarrheic rabbits was identified and sequenced. The genotype constellation of Z3171 is G3-P[22]-I2-R3-C3-M3-A9-N2-T1-E3-H3, which is different from the constellation observed in previously characterized LRV strains. However, the genome of Z3171 differed substantially from those of the rabbit rotavirus strains N5 and Rab1404 in terms of both gene content and gene sequence. Our study suggests that either a reassortment event occurred between human and rabbit rotavirus strains or there are undetected genotypes circulating in the rabbit population. This is the first report of detection of a G3P[22] RVA strain in rabbits in China.

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Data Availability

The datasets generated and/or analyzed in the current study are available in the GenBank database and in the online supplementary materials.

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Acknowledgements

This research was funded by Shandong Modern Agricultural Technology & Industry System, grant number SDAIT-21-06Key Research and Development Program of Shandong Province (2022CXGC010606).

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Authors and Affiliations

  1. MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, 210095, Nanjing, Jiangsu Province, China

    Qiaoya Zhao & Qiusheng Chen

  2. Institute of Poultry Sciences, Shandong Academy of Agricultural Sciences, 250023, Jinan, Shandong Province, China

    Qiaoya Zhao, Liping Liu, Ye Tian, Xiaozhen Guo, Cunxia Liu & Bing Huang

  3. College of Veterinary Medicine, Southwest University, 402460, Chongqing, China

    Tao Huang

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  1. Qiaoya Zhao
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by all authors. The first draft of the manuscript was written by Z. QY, L. LP, and H. T, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Bing Huang or Qiusheng Chen.

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Communicated by Tim Skern

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Zhao, Q., Liu, L., Huang, T. et al. Complete genomic analysis of rabbit rotavirus G3P[22] in China. Arch Virol 168, 129 (2023). https://doi.org/10.1007/s00705-023-05740-7

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