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Multiple reassortment and interspecies transmission events contribute to the diversity of porcine-like human rotavirus C strains detected in South Korea

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Abstract

Globally, rotavirus C (RVC) causes diarrhoeal outbreaks, mainly in swine, with sporadic incidents in human, bovine, and canine populations. In this study, two human RVC strains, RVC/Human-wt/KOR/CAU13-1-77/2013 and RVC/Human-wt/KOR/CAU14-1-242/2014, were isolated in South Korea, and their complete genome sequences were compared with those of other human- and animal-origin RVC strains found worldwide. Genetic analysis revealed that these viruses have a G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype constellation. Phylogenetic analysis indicated that these Korean RVC strains belong to the M3 lineage of the VP3 gene in human RVC from Japan and China and porcine RVC from Japan. These results suggest that RVC circulates in northeast Asia in both the human and porcine populations. These results also provide evidence of interspecies RVC reassortment events.

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The nucleotide sequences obtained in this study were deposited in the GenBank database at NCBI under the accession numbers KT284776–KT284786 for the CAU14-1-242 strain and KT355386–KT355396 for the CAU13-1-77 strain.

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Authors and Affiliations

  1. Department of Microbiology, Chung-Ang University College of Medicine, 06974, Seoul, South Korea

    Thoi Cong Truong & Wonyong Kim

  2. Central Vietnam Veterinary Institute, Nha Trang, Vietnam

    Tinh Huu Nguyen

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  1. Thoi Cong Truong
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  2. Tinh Huu Nguyen
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  3. Wonyong Kim
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Contributions

Conceived and designed the experiments: W. K. Performed the experiments: T. C. T. Data analysis: T. H. N. Contributed reagents, materials, and analysis tools: W. K. Wrote the paper: T. C. T. and W. K.

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Correspondence to Wonyong Kim.

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The authors declare no competing interests.

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This study was performed according to protocols approved by the Human Subjects Institutional Review Board (IRB) of Chung-Ang University Hospital (Protocol number 1710-009-303).

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Written informed consent was obtained from all participants.

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Handling Editor Tim Skern

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Truong, T.C., Nguyen, T.H. & Kim, W. Multiple reassortment and interspecies transmission events contribute to the diversity of porcine-like human rotavirus C strains detected in South Korea. Arch Virol 167, 2163–2171 (2022). https://doi.org/10.1007/s00705-022-05528-1

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