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Antibody prophylaxis against Tembusu virus-associated disease

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Abstract

Earlier studies have shown that Tembusu virus (TMUV) can elicit high levels of neutralizing antibodies, but the ability of antibodies to protect against TMUV-associated disease and to inhibit replication of TMUV in vivo remains to be investigated. Here, we tested the prophylactic efficacy of TMUV immune serum directly using a 2-day-old Pekin duck model. Passive administration of the immune serum prior to challenge protected ducklings against morbidity and mortality, substantially reduced TMUV-caused tissue injury, and significantly decreased TMUV levels in the periphery and central nervous system. These findings demonstrate that antibodies play a dominant protective role in controlling TMUV-associated disease.

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Funding

This study was supported by the China Agriculture Research System of MOF and MARA and the National Key Research and Development Program of China (2016YFD0500107).

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Authors and Affiliations

  1. Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People’s Republic of China

    Qiong Li, Chonglun Feng, Baolin Yang, Runze Meng, Xiaoyan Wang & Dabing Zhang

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  1. Qiong Li
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  2. Chonglun Feng
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  3. Baolin Yang
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  4. Runze Meng
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  5. Xiaoyan Wang
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  6. Dabing Zhang
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Corresponding author

Correspondence to Dabing Zhang.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures involving ducks were approved by the Animal Welfare and Ethical Censor Committee at China Agricultural University (license no. AW22011202-2-2).

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Handling Editor: Patricia Aguilar.

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Cite this article

Li, Q., Feng, C., Yang, B. et al. Antibody prophylaxis against Tembusu virus-associated disease. Arch Virol 167, 1687–1691 (2022). https://doi.org/10.1007/s00705-022-05460-4

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  • DOI: https://doi.org/10.1007/s00705-022-05460-4

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