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Biological characterization and genomic analysis of Acinetobacter baumannii phage BUCT628

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Abstract

Acinetobacter baumannii is an opportunistic pathogen that is resistant to the most commonly used antibiotics. In this study, the Acinetobacter phage BUCT628 was isolated from hospital wastewater. BLASTn analysis showed that the genome sequence of BUCT628 shared 89.76% identity with 66% query coverage with that of Acinetobacter phage Bphi-R2919. Genome sequencing showed that the BUCT628 genome is a 44,935-bp linear dsDNA molecule with 37.5% G+C content and 86 open reading frames (ORFs), and no tRNAs were identified.

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Funding

This research was supported by Funds for First-class Discipline Construction (nos. XK1805 and XK1803-06), the National Key Research and Development Program of China (nos. 2018YFA0903000, 2020YFC2005405, 2020YFA0712100, 2020YFC0840805, 19SWAQ06, 20SWAQX27, and 20SWAQK22), the Inner Mongolia Key Research and Development Program (no. 2019ZD006), the NSFC-MFST project (China-Mongolia) (no. 31961143024), and the Fundamental Research Funds for Central Universities (nos. BUCTRC201917 and BUCTZY2022).

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Authors and Affiliations

  1. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China

    Yinuo Zhu, Ke Han, Long Chen, Shizhong Luo, Huahao Fan & Yigang Tong

  2. Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China

    Yigang Tong

Authors
  1. Yinuo Zhu
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  2. Ke Han
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  3. Long Chen
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  4. Shizhong Luo
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  5. Huahao Fan
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  6. Yigang Tong
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Contributions

YZ: resources, data curation, writing—original draft, investigation. KH: data curation, investigation, validation. LC: supervision, writing—review and editing. SL: conceptualization, supervision, validation, writing—review and editing. HF: supervision, writing—review and editing. YT: conceptualization, supervision, validation, writing—review and editing.

Corresponding authors

Correspondence to Long Chen, Shizhong Luo, Huahao Fan or Yigang Tong.

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Conflict of interest

All authors declare that they have no competing interests.

Nucleotide sequence accession number

The complete genome sequence of phage BUCT628 with annotations was submitted to the GenBank database under the accession number MZ593728.1.

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Handling Editor: Johannes Wittmann.

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Zhu, Y., Han, K., Chen, L. et al. Biological characterization and genomic analysis of Acinetobacter baumannii phage BUCT628. Arch Virol 167, 1471–1474 (2022). https://doi.org/10.1007/s00705-022-05425-7

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  • DOI: https://doi.org/10.1007/s00705-022-05425-7

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