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The first third-generation HIV-1 circulating recombinant form (CRF114_0155) identified in central China

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Abstract

A novel circulating recombinant form (CRF) was identified in eight HIV-1-infected patients without direct epidemiological relationships in Henan Province, Central China. Recombination analysis indicated that the genome of this novel CRF comprises five segments: three inherited from CRF01_AE cluster-4 and two from CRF55_01B. Therefore, the CRF was designated CRF114_0155. It is not only the first novel CRF identified in Henan Province but also the first third-generation CRF of HIV-1 and the first CRF descendant of CRF55_01B. Bayesian inference of phylogeny dated the most recent common ancestor of the CRF114_0155 cluster to 2010. The emergence of CRF114_0155 reflects that the genotype constitution of HIV-1 has become more complex and that stricter intervention measures should be implemented in central China.

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Funding

This work was supported by the National Natural Science Foundation of China and the National Science and Technology Major Project of China during the 13th Five-Year Plan period (No. 31761133007 and No. 2018ZX10302104).

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Authors and Affiliations

  1. Unit of HIV Molecular Epidemiology and Virology, State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China

    Yang Li, Yan Zhang, Wenying Wu & Rongge Yang

  2. Anyang Center for Disease Control and Prevention, Anyang, 455000, China

    Yang Li, Long Liu, Hui Chen & Shuanhu Zhang

  3. University of Chinese Academy of Sciences, Beijing, 100049, China

    Yang Li & Yan Zhang

  4. Institute of Medical Biology, Peking Union Medical College and Chinese Academy of Medical Sciences, Kunming, 650031, China

    Hongye Wang

  5. AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan

    Rongge Yang

  6. Division of Infectious Disease, Chongqing Public Health Medical Center, Chongqing, 400036, China

    Rongge Yang

  7. Sino-German Virtual Institute for Viral Immunology (SGVIVI), Essen, Germany

    Rongge Yang

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  1. Yang Li
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  2. Yan Zhang
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Correspondence to Rongge Yang.

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The authors declare that they have no conflicts of interest.

Ethical approval

This study was approved by the Ethics Review Committee of Anyang Municipal Center for Disease Prevention and Control, and written informed consent was obtained from all patients.

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Handling Editor: Zhongjie Shi.

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Li, Y., Zhang, Y., Wang, H. et al. The first third-generation HIV-1 circulating recombinant form (CRF114_0155) identified in central China. Arch Virol 166, 3409–3416 (2021). https://doi.org/10.1007/s00705-021-05213-9

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  • DOI: https://doi.org/10.1007/s00705-021-05213-9

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